SARS

Exploring age-associated differences in T lymphocyte immune responses after BNT162b2 vaccination

In a recent study posted to the bioRxiv* preprint server, researchers compared the immunogenicity of, and reactogenicity to, the BNT162b2 vaccine, a coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA) vaccine, in Japanese adults and elders. Study: Delayed antigen-specific CD4+ T-cell induction correlates with impaired immune responses to SARS-COV-2 mRNA vaccination in the elderly. Image …

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CDC study of pregnant women hospitalized with COVID in 2021 found 93% not vaccinated

In a recent study posted to the Research Square* preprint server, researchers assessed the characteristics and treatment of coronavirus disease 2019 (COVID-19) in pregnant women. Various studies have reported that pregnant women are at a higher risk of severe disease outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Despite this, a significant number …

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Simulating molecular dynamics of SARS-CoV-2 spike variants in the locked conformation

In a recent study posted to the bioRxiv* pre-print server, researchers retrieved the first-ever sequenced spike (S) protein structures of the original Wuhan-Hu 1 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain, the Alpha, Delta, Delta-plus variants , and Omicron sub-variants BA.1 and BA.2 and compared their structural and molecular level variations. Study: Molecular dynamics …

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Severe symptoms result in high titers of SARS-CoV-2 antibodies

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the novel coronavirus, namely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has drastically affected the global healthcare system and economy. SARS-CoV-2 causes asymptomatic to severe infection, which sometimes results in death. Scientists observed that active replication of the virus occurs in the early stage of the …

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Third BNT162b2 dose elicits more durable immune response than second dose

In a recent study posted to the medRxiv* preprint server, researchers evaluated the durability of immune responses post-third dose of the BNT162b2 vaccine. Study: Durability of the immune response to a third BNT162b2 dose; five months follow-up. Image Credit: Telnov Oleksii/Shutterstock The coronavirus disease 2019 (COVID-19) pandemic has negatively affected human lives and remains an …

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Researchers investigate IgG antibodies against Mtb proteins in an Asian elephant cured of tuberculosis

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (mtb); the leading cause of human death due to a single pathogen before the emergence of SARS-CoV-2. In elephants, the infections and deaths with TB have been reported worldwide, and elephant-to-human transmission has also been reported. Therefore, elephant TB is a concern for both conservation …

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The potential impact of oral vaccination against COVID-19 on transmission to naïve individuals studied in a hamster infection model

A recent article published in Science Translational Medicine demonstrated that mucosally delivered adenovirus type 5 (Ad5)-based coronavirus disease 2019 (COVID-19) vaccination minimized COVID-19 transmission and severity. Study: Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model. Image Credit: sdecoret/Shutterstock Background The currently approved intramuscular (IM) severe …

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Diagnostic performance of monocyte distribution width and other leukocyte parameters for SARS-CoV-2 and influenza infection

In a recent study posted to the Research Square* preprint server, researchers used a novel diagnostic screen, monocyte distribution width (MDW) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza infection. Study: Monocyte Distribution Width as a Pragmatic Diagnostic Screen for SARS-CoV-2 and Influenza Infection. Image Credit: Corona Borealis Studio/Shutterstock Background MDW, a measure …

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Effectiveness of BNT162b2 third dose against Omicron-associated severe disease

In a recent study posted to the medRxiv* preprint server, researchers analyzed the effectiveness of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BNT162b2 third vaccine dose against SARS-CoV-2 Omicron-induced severe infection nearly seven months post-vaccination. Study: Protection against omicron severe disease 0-7 months after BNT162b2 booster. Image Credit: peterschreiber.media/Shutterstock Background Following an increase in …

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Evidence of croup associated with SARS-CoV-2

Croup, inflammation of the subglottic upper airway mucosa manifest as respiratory distress airflow obstruction in children. In addition, it is associated with epithelial-level edema, and most emergency department (ED) admissions occur due to an acute viral infection. Study: Croup Associated With SARS-CoV-2: Pediatric Laryngotracheitis During the Omicron Surge. Image Credit: rumruay/Shutterstock The frequency of the …

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